Asociación entre la deficiencia de hierro y zinc, y la aparición de síntomas depresivos en adultos

  • Isabella Martínez Marulanda Pontificia Universidad Javeriana Cali
  • Sergio Andrés Medina Fandiño Pontificia Universidad Javeriana Cali
  • Natalia Jiménez Cardozo Pontificia Universidad Javeriana Cali http://orcid.org/0000-0002-7206-499X
Palabras clave: Hierro, Zinc, Deficiencia, Depresión, Síntomas depresivos

Resumen

Introducción: El hambre oculta se define como la desnutrición resultante por la carencia de micronutrientes, común tanto en los países en vía de desarrollo como los países desarrollados. Existe evidencia de la asociación entre la carencia de zinc y hierro y la aparición de trastornos del estado del ánimo, especialmente síntomas depresivos. Esta revisión buscó analizar y comparar algunos de los datos de estudios clínicos en relación con las concentraciones de zinc y hierro en sangre, así como la ingesta de zinc y hierro en la dieta, entre sujetos adultos con y sin síntomas depresivos. Materiales y métodos: Se realizó una búsqueda en las bases de datos PubMed y Embase empleando los términos MeSH “Zinc”, “Iron”, “Depression”, “Depressive symptoms”, incluyendo estudios observacionales con fecha de publicación no mayor a 10 años. Resultados: Se analizaron un total de 10 artículos para zinc y 9 para hierro, todos con muestra heterogénea y distintas escalas para medir síntomas depresivos y para valorar la ingesta de ambos micronutrientes. La mayoría de estudios incluidos, mostró asociación positiva entre déficit de micronutrientes y síntomas depresivos en adultos. Conclusión: Existe asociación entre la presencia de síntomas depresivos y una menor concentración sanguínea de hierro y zinc y un menor consumo de hierro y zinc en la dieta. Sin embargo, dada la heterogeneidad de los datos, se requiere más investigación clínica que permita describir mejor esta asociación y definir los potenciales beneficios de la suplementación en pacientes con síntomas depresivos.

Abstract:

Introduction: Hidden hunger is defined as the malnutrition resulting from the lack of micronutrients, common in both developing and developed countries. There is evidence of an association between zinc and iron deficiency and the appearance of mood disorders, especially depressive symptoms. This review sought to analyze and compare some of the data from clinical studies regarding blood zinc and iron concentrations, as well as dietary zinc and iron intake, among adult subjects with and without depressive symptoms. Materials and methods: A search of the PubMed and Embase databases was performed using the MeSH terms “Zinc”, “Iron”, “Depression”, “Depressive symptoms”, including observational studies with a publication date of no more than 10 years. Results: A total of 10 articles were analyzed for zinc and 9 for iron, all with a heterogeneous sample and different scales to measure depressive symptoms and to assess the intake of both micronutrients. Most of the included studies showed a positive association between micronutrient deficits and depressive symptoms in adults. Conclusion: There is an association between the presence of depressive symptoms and a lower blood concentration of iron and zinc and a lower consumption of iron and zinc in the diet. However, given the heterogeneity of the data, more clinical research is required to better describe this association and define the potential benefits of supplementation in patients with depressive symptoms.

Key words: Iron, zinc, depression, deficiency, depressive symptoms.

Biografía del autor/a

Isabella Martínez Marulanda, Pontificia Universidad Javeriana Cali

Estudiante de medicina. Semillero de Innovadores en Salud ISSEM

Sergio Andrés Medina Fandiño, Pontificia Universidad Javeriana Cali

Estudiante de medicina. Semillero de Innovadores en Salud ISSEM

Natalia Jiménez Cardozo, Pontificia Universidad Javeriana Cali

Médica, Magíster en Ciencias Biomédicas, Profesora Departamento de Ciencias de la Salud

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Publicado
2020-04-03
Cómo citar
Martínez Marulanda, I., Medina Fandiño, S., & Jiménez Cardozo, N. (2020). Asociación entre la deficiencia de hierro y zinc, y la aparición de síntomas depresivos en adultos. Salutem Scientia Spiritus, 6(1), 27-39. Recuperado a partir de https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/2259