Aspectos neuropatológicos y manifestaciones clínicas asociadas al covid-19: una revisión de la literatura.

Palabras clave: Coronavirus, COVID-19, manifestaciones neurológicas, sistema nervioso, trastornos neurológicos.

Resumen

Los primeros casos de un nuevo Coronavirus fueron identificados en pacientes con neumonía atípica en Wuhan (China) en diciembre del 2019. Esta enfermedad primero conocida como Coronavirus por el patógeno que la genera, posteriormente bautizada COVID-19 y actualmente referida como SARS-CoV-2 ha sido calificada como una pandemia por la Organización Mundial de la Salud (OMS) desde marzo del 2020. El objetivo de este trabajo es desarrollar una revisión narrativa de la literatura mediante estrategias avanzadas de búsqueda para describir la información producida hasta el momento en relación con los aspectos fisiopatológicos que afectan el sistema nervioso y las manifestaciones clínicas neurológicas secundarias relacionadas con COVID-19. Se realizó una búsqueda de la literatura en las bases de datos de PubMed-Medline, enfatizando en la lectura crítica de 12 de estos artículos. Se han observado síntomas neurológicos en pacientes con COVID-19 en China, estos se agrupan en varias categorías, incluidos los relacionados con enfermedad cerebrovascular aguda, infección intracraneal, sistema nervioso periférico y síntomas neuromusculares. Hasta el momento no se ha podido concluir con seguridad la relación causal entre manifestaciones neurológicas y la infección por SARS-CoV-2.

Abstract:

The first cases of a new Coronavirus were identified in patients with atypical pneumonia in Wuhan, China in December 2019. This disease was first known as Coronavirus due to the pathogen that generates it, later named COVID-19 and currently referred to as SARS-COV-2. It has been classified as a pandemic by the World Health Organization (WHO) since March 2020. The objective of this work is to develop a narrative review of the literature using advanced search strategies to describe the information produced so far in relation to the pathophysiological aspects that affect the nervous system and the secondary neurological clinical manifestations related to COVID-19. A search of the literature in the PubMed-Medline databases was performed, emphasizing the critical reading of 12 of these articles. Neurological symptoms have been observed in patients with COVID-19 in China, these are grouped into several categories, including those related to acute cerebrovascular disease, intracranial infection, peripheral nervous system and neuromuscular symptoms. So far, it has not been found to conclude with certainty the causal relationship between neurological manifestations and SARS-COV-2 infection.

Key words: Coronavirus, SARS-OV-2, COVID-19, neurological disorders, nervous system, neurophysiopathology.

 

Biografía del autor/a

Juan Pablo García-Marmolejo, Pontificia Universidad Javeriana Cali

Estudiante de medicina, Semillero de Innovadores en Salud ISSEM.

Valeria Valencia-Cifuentes, Universidad ICESI

Médica, Residente Especialización en Neurología

Citas

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Publicado
2020-08-12
Cómo citar
García-Marmolejo, J., & Valencia-Cifuentes, V. (2020). Aspectos neuropatológicos y manifestaciones clínicas asociadas al covid-19: una revisión de la literatura. Salutem Scientia Spiritus, 6(1), 76-87. Recuperado a partir de https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/2336