Cambios genéticos del SARS-CoV-2.

Genetic changes of SARS-CoV-2

Palabras clave: COVID-19, SARS-CoV-2, Genética, Betacoronavirus, Genoma humano, Mutación, Coronavirus

Resumen

Objetivo: Determinar los cambios genéticos del SARS-CoV-2. Materiales y métodos: Se realizó una búsqueda sistemática en las bases de datos electrónicas MEDLINE, EMBASE, y bioRxiv. Se utilizaron términos MeSH y DeCS y se seleccionaron 18 artículos publicados a partir del año 2019, en los idiomas inglés y español. Resultados: Se encontraron nueve mutaciones en ORF1ab, una mutación en el gen ORF7a, y 13 mutaciones en el gen S en varios países después de febrero 2020, distintos de la cepa del genoma de referencia inicial de Wuhan (China). Finalmente, se identificó recombinación entre cepas pandémicas del virus. Conclusiónes: El SARS-CoV-2 es un virus emergente del cual se está estudiando extensamente su genoma para identificar cuáles mutaciones han contribuido al impacto clínico. Con esta revisión se intentó dilucidar e identificar los cambios genéticos a lo largo de su evolución. Sin embargo, se hace necesario más estudios en otros países. Adicionalmente, es importante continuar monitoreando los cambios genéticos del SARS-CoV-2 para conocer el impacto que esto tendría en las terapias y vacunas a utilizar.

Abstract:

Aim: Determine the genetic changes in SARS-CoV-2. Materials and methods: A systematic search of the electronic databases MEDLINE, EMBASE, and bioRxiv was performed. Terms MeSH and DeCS were used, and 18 articles published from the year 2019, in the English and Spanish languages, were selected. Results: We found 9 mutations in ORF1ab gene, one mutation in the ORF7a gene, and 13 mutations in the S gene in various countries after February 2020, different from the initial reference strain of Wuhan (China) genome. Finally, recombination between pandemic strains of the virus was identified. Conclusions: SARS-CoV-2 is an emerging virus whose genome is being studied extensively to identify which mutations have contributed to the clinical impact. With this review we tried to elucidate and identify the genetic changes throughout its evolution. However, more studies in other countries are necessary. Additionally, it is important to continue monitoring the genetic changes of SARS-CoV-2 to know the impact that this would have on the therapies and vaccines to be used.

Key words: COVID-19, SARS-CoV-2, genetics, Betacoronavirus, human genoma, mutation, Coronavirus.

Biografía del autor/a

Juliana Montaña-Otero, Pontificia Universidad Javeriana Cali

Estudiante de medicina, Semillero de Innovadores en Salud ISSEM.

Ana Sofia Cordoba-Naranjo, Pontificia Universidad Javeriana Cali

Estudiante de medicina, Semillero de Innovadores en Salud ISSEM.

Citas

Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. International Journal of Biological Sciences. 2020; 16:1678-1685. DOI: 10.7150/ijbs.45053

Coronavirus Disease (COVID-19) Situation Reports. WHO; 2020. Disponible en: https://www.who.int/emergencies /diseases/novel-coronavirus-2019/situation-reports/

Reina J. El SARS-CoV-2, una nueva zoonosis pandémica que amenaza al mundo. Vacunas. 2020. DOI: 10.1016/j.vacun.2020.03.001

Trilla A. One world, one health: The novel coronavirus COVID-19 epidemic. Med Clin (Barc). 2020; 154(5):175-7. DOI: 10.1016/j.medcli.2020.02.002

Rodriguez-Morales AJ, Bonilla-Aldana DK, Balbin-Ramon GJ, Rabaan AA, Sah R, Paniz-Mondolfi A et al. History is repeating itself: Probable zoonotic spillover as the cause of the 2019 novel coronavirus epidemic. Infez Med. 2020; 28(1):3-5.

Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020; 24:91-8. DOI: 10.1016/j.jare.2020.03.005

Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P et al. Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host Microbe. 2020 ; 27(3):325-8. Available from: DOI: 10.1016/j.chom.2020.02.001

Pastrian-Soto G. Bases Genéticas y Moleculares del COVID-19 (SARS-CoV-2). Mecanismos de Patogénesis y de Respuesta Inmune. Int J Odontostomatol. 2020; 14(3):331-7.

Khailany RA, Safdar M, Ozaslan M. Genomic characterization of a novel SARS-CoV-2. Gene Rep. 2020; 19:100682. DOI: 10.1016/j.genrep.2020.100682

Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P et al. Emerging SARS ‑ CoV ‑ 2 mutation hot spots include a novel RNA ‑ dependent ‑ RNA polymerase variant. Journal of Translational Medicine. 2020; 18(179):1-9. DOI: 10.1186/s12967-020-02344-6

Dorp L. Van Acman M, Richard D, Shaw LP. Ford CE, Ormond L et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infection, Genetics and Evolution. 2020; 104351. DOI: 10.1016/j.meegid.2020.104351

Koyama T, Platt D, Parida L. Variant analysis of SARS-CoV-2 genomes [data repository]. Meyrin: European Organization for Nuclear Research. 2020. DOI: 10.2471/BLT.20.253591

Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q et al. Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. bioRxiv. 2020; 2020.07.02.184481. DOI: 10.1101/2020.07.02.184481

Naqvi AAT, Fatima K, Mohammad T et al. Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. Biochim Biophys Acta Mol Basis Dis. 2020; 1866(10):165878. DOI: 10.1016/j.bbadis.2020.165878

Holland LA, Kaelin EA, Maqsood R, Bereket E, Wu LI, Varsani A et al. An 81 nucleotide deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020). Journal of Virology. 2020. DOI: 10.1128/JVI.00711-20

Addetia A, Xie H, Roychoudhury P et al. Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates. J Clin Virol. 2020; 129:104523. DOI: 10.1016/j.jcv.2020.104523

Korber B, Wm F, Gnanakaran S, Yoon H, Theiler J, Abfalterer W et al. Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2. bioRxiv. 2020; 1-33. DOI: 10.1101/2020.04.29.069054

Korber B, Fischer W, Gnanakaran S, Yoon H, Theiler J, Abfalterer W et al. On behalf of the Sheffield COVID-19 Genomics Group, Tracking changes in SARS-CoV-2 Spike: Evidence that D614G increases infectivity of the COVID-19 virus. Cell. 2020. DOI: 10.1016/j.cell.2020.06.043.

Publicado
2020-08-12
Cómo citar
Montaña-Otero, J., & Cordoba-Naranjo, A. (2020). Cambios genéticos del SARS-CoV-2. Salutem Scientia Spiritus, 6(1), 88-93. Recuperado a partir de https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/2339