Cannabis and osteoarthritis, a new trend for the management of chronic rheumatic pain

Authors

  • Diana Marcela Cerquera-Gerena Pontificia Universidad Javeriana Cali (Colombia)
  • Carlos Enrique Mira-Angel Pontificia Universidad Javeriana Cali (Colombia)
  • Silverio Garzón Pontificia Universidad Javeriana Cali (Colombia) https://orcid.org/0000-0002-7168-023X

Abstract

Osteoarthritis is an inflammatory joint condition characterized by the destruction of hyaline cartilage, leading to mechanical-type pain causing stiffness in the affected area accompanied by decreased mobility. It significantly impairs the quality of life of those affected, as motor skills deteriorate, progressing to functional disability. Currently, we have a diverse range of analgesic drugs used in rheumatologic pain, among which the most popular are non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. However, as the condition progresses, these drugs may not provide the expected relief, and we also face side effects, opioid addiction, and affectation of the individual's mood. Therefore, the use of cannabis emerges as another option, aiming to find medications that offer better results. This article intends to compile evidence regarding this new therapeutic trend and understand if using cannabis is a viable and effective alternative for managing chronic joint pain.

Downloads

Download data is not yet available.

Author Biographies

Diana Marcela Cerquera-Gerena, Pontificia Universidad Javeriana Cali (Colombia)

Estudiante de Medicina

Carlos Enrique Mira-Angel, Pontificia Universidad Javeriana Cali (Colombia)

Estudiante de Medicina

Silverio Garzón, Pontificia Universidad Javeriana Cali (Colombia)

Biólogo, Magíster en Ciencias Biomédicas, Doctor en Ciencias Biomédicas, Profesor Departamento de Ciencias Básicas de la Salud.

References

Góngora YL, Friol JE, Rodríguez EM, González JL, Castellanos M, Álvarez R. Calidad de vida en pacientes con osteoartrosis de cadera y rodilla. Rev Cubana Reumatol. 2006; 8(9y10):23-42.

Londoño J, Peláez Ballestas I, Cuervo F, Angarita I, Giraldo R, Rueda JC, et al. Prevalencia de la enfermedad reumática en Colombia, según estrategia COPCORD-Asociación Colombiana de Reumatología. Estudio de prevalencia de enfermedad reumática en población colombiana mayor de 18 años. Rev Colomb Reumatol. 2018; 25(4):245-56.

Coordinadores F, José J, Sendín R, Ingrid D, Parera M, Basallote SG, et al. Guía de Buena Práctica Clínica en Artrosis. Cgcom.es. Disponible en: https://www.cgcom.es/sites/main/files/mig/guia_artrosis_edicion2.pdf

Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Opioid complications and side effects. Pain Physician. 2008; 11(2 Suppl):S105-20.

Anastasiou C, Yazdany J. Review of publications evaluating opioid use in patients with inflammatory rheumatic disease. Curr Opin Rheumatol. 2022 Mar 1;34(2):95-102. DOI: 10.1097/BOR.0000000000000868.

Schaiquevich P, Riva N, Maldonado C, Vázquez M, Cáceres-Guido P. Farmacología clínica de cannabidiol en epilepsias refractarias. Farm Hosp. 2020; 44(5): 22-229. DOI: 10.7399/fh.11390.

Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003; 42(4):327-60. DOI: 10.2165/00003088-200342040-00003.

Amin MR, Ali DW. Pharmacology of Medical Cannabis. Adv Exp Med Biol. 2019; 1162:151-165. DOI: 10.1007/978-3-030-21737-2_8

Atakan Z. Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology. 2012, 2(6):241-254. DOI: 10.1177/2045125312457586

Philpott HT, OʼBrien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. European Journal of Pain. 2018; 22(3):436-448. DOI: 10.1002/ejp.1140

Lowin T, Schneider M, Pongratz G. Joints for joints: cannabinoids in the treatment of rheumatoid arthritis. Current Opinion in Rheumatology. 2019; 31(3):271-8.

Vidal Fuentes J. Artrosis y dolor: la complejidad e impacto de un síntoma. Rev Soc Esp Dolor. 2021; 28:1-3.

Mayoral Rojals V. Epidemiología, repercusión clínica y objetivos terapéuticos. Rev Soc Esp Dolor. 2021; 28:4-10.

Mandl LA. Osteoarthritis year in review 2018: clinical. Osteoarthritis Cartilage. 2019 Mar;27(3):359-364. DOI: 10.1016/j.joca.2018.11.001. Epub 2018 Nov 16. PMID: 30453055

Fader L, Scharf Z, DeGeorge BR Jr. Assessment of Medical Cannabis in Patients With Osteoarthritis of the Thumb Basal Joint. J Hand Surg Am. 2023; 48(3):257-262.e1. DOI: 10.1016/j.jhsa.2021.10.018.

Dunn SL, Wilkinson JM, Crawford A, Bunning RAD, Le Maitre CL. Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies. Cannabis Cannabinoid Res. 2016; 1(1):3-15. DOI: 10.1089/can.2015.0001

Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, Kendall DA, Scammell BE, Reeve AJ, Chapman V. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. 2008; 10(2):R43. DOI: 10.1186/ar2401

García-Henares JF, de Santiago-Moraga J. Evidencia científica actualizada del tratamiento con cannabis medicinal en pacientes con dolor crónico. Rev Soc Esp Dolor. 2022; 29(Suppl 1):10-13. DOI: 10.20986/resed.2022.4024/2022.

Maurer GE, Imperato NS, Juybari CM, Kincaid H, Koons A. The Utility of Cannabis-Based Medicine in Chronic Pain Management: A Case Report. Cureus. 2022; 14(11):e31555. DOI: 10.7759/cureus.31555

Fitzcharles MA, Baerwald C, Ablin J, Häuser W. Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis): A systematic review of randomized controlled trials. Schmerz. 2016; 30(1):47-61. DOI: 10.1007/s00482-015-0084-3

Boehnke KF, Litinas E, Clauw DJ. Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain. J Pain. 2016; 17(6):739-44. DOI: 10.1016/j.jpain.2016.03.002

Boehnke KF, Litinas E, Clauw DJ. Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain. J Pain. 2016; 17(6):739-44. DOI: 10.1016/j.jpain.2016.03.002

Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J. Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA. 2015; 313(24):2456-73. DOI: 10.1001/jama.2015.6358

Published

2023-03-31

How to Cite

Cerquera-Gerena, D. M., Mira-Angel, C. E., & Garzón, S. (2023). Cannabis and osteoarthritis, a new trend for the management of chronic rheumatic pain. Salutem Scientia Spiritus, 10(1), 66–71. Retrieved from https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1332

Issue

Section

Revisión de la literatura