Etiology and risk factors of carpal tunnel syndrome: A literature review.

Authors

  • Karolina María Otero-Argel Pontificia Universidad Javeriana Cali (Colombia) https://orcid.org/0009-0008-6114-7483
  • Vivian Vanessa Rivera-Figueroa Pontificia Universidad Javeriana Cali (Colombia)
  • Camilo Salazar-Barney Pontificia Universidad Javeriana Cali (Colombia)
  • Angelica María Ruiz-Ortiz Pontificia Universidad Javeriana Cali (Colombia)

Keywords:

Carpal tunnel syndrome, risk factors, etiology.

Abstract

Carpal Tunnel Syndrome (CTS) is the most common neuropathy affecting the upper limb. Currently, a large part of the population is exposed to different types of occupations and manual labor that lead to pathologies such as CTS. The objective of this literature review is to determine the etiology of CTS, as well as to identify the main risk factors recognized in the literature for the onset and development of CTS. The present text compiles various literature related to CTS, risk factors, and the pathology's etiology; especially review articles, systematic reviews, and meta-analyses selected from PubMed, using MeSH terms.  For articles related to risk factors, a time window from 2006 to 2022 was determined and a time window from 2017 to 2020 for etiology-related articles; resulting in the inclusion of 11 articles in the review. As a result, different types of risk factors were identified, including exposure to force along with a high rate of repetitiveness, hand-arm vibrations, and prolonged work with the wrist-arm flexed. It was also found that CTS is influenced by the type of occupation, with occupations such as the meat and fishing industry, jobs involving chainsaws, or electronic assemblies being risk factors for the development of the pathology. Similarly, gender was identified as a risk factor, particularly the female gender, and middle-aged patients as more susceptible to developing this pathology. Likewise, pre-existing conditions such as rheumatoid arthritis, diabetes mellitus type I and II, and obesity were recognized as risk factors for CTS. Finally, two reviewed articles found an existing relationship between psychosocial factors such as work stress, job pressure, among others, and CTS. In conclusion, the findings of this literature review suggest biomechanical risk factors such as repetitiveness and applied force, as well as etiological factors such as age, gender, occupation, and pre-existing pathologies for the development and onset of CTS.

Downloads

Download data is not yet available.

Author Biographies

  • Karolina María Otero-Argel, Pontificia Universidad Javeriana Cali (Colombia)

    Ingeniera Biomédica.

  • Vivian Vanessa Rivera-Figueroa, Pontificia Universidad Javeriana Cali (Colombia)

    Ingeniera Biomédica.

  • Camilo Salazar-Barney, Pontificia Universidad Javeriana Cali (Colombia)

    Ingeniero Biomédico.

  • Angelica María Ruiz-Ortiz, Pontificia Universidad Javeriana Cali (Colombia)

    Ingeniera Biomédica.

References

1. Hassan A, Beumer A, Kuijer PPFM, van der Molen HF. Work-relatedness of carpal tunnel syndrome: Systematic review including meta-analysis and GRADE. Health Sci Rep. 2022; 5(6):e888. DOI: 10.1002/hsr2.888

2. Tamayo D. Factores de riesgo biomecánicos asociados al desarrollo del síndrome del túnel del carpo en el contexto laboral: una revisión bibliográfica. Disponible: https://www.ist.cl/wp-content/uploads/2021/04/FACTORES-DE-RIESGO-BIOMEC%C3%81NICOS-ASOCIADOS-AL-DESARROLLO-DEL-S%C3%8DNDROME-DEL-T%C3%9ANEL-DEL-CARPO-EN-EL-CONTEXTO-LABORAL-UNA-REVISI%C3%93N-BIBLIOGR%C3%81FICA.pdf

3. Van Rijn RM, Huisstede BMA, Koes BW, Burdorf A. Associations between work-related factors and the carpal tunnel syndrome. A systematic review. Scand J Work Environ Health. 2009; 35(1):19-36. DOI: 10.5271/sjweh.1306.

4. Palmer KT, Harris EC, Coggon D. Carpal tunnel syndrome and its relation to occupation: a systematic literature review. Occup Med (Lond). 2007; 57(1):57-66. DOI: 10.1093/occmed/kql125.

5. Spahn G, Wollny J, Hartmann B, Schiele R, Hofmann G. Metaanalyse zur Bestimmung von Risikofaktoren für das Karpaltunnelsyndrom (KTS) Teil II. Berufliche Risikofaktoren, Zeitschrift für Orthopädie und Unfallchirurgie. 2012; 150(5):516-524. DOI: 10.1055/s-0032-1315346

6. Thomsen JF, Gerr F, Atroshi I. Carpal tunnel syndrome and the use of computer mouse and keyboard: a systematic review. BMC Músculoskelet Disord . 2008: 9:134. DOI: 10.1186/1471-2474-9-134.

7. Lavé A, Gondar R, Demetriades AK, Meling TR. Ergonomics and músculoskeletal disorders in neurosurgery: a systematic review. Acta Neurochir (Wien). 2020; 162(9):2213-2220. DOI: 10.1007/s00701-020-04494-4

8. Spahn G, Wollny J, Hartmann B, Schiele R, Hofmann G. Metaanalyse zur Bestimmung von Risikofaktoren für das Karpaltunnelsyndrom (KTS) Teil I. Allgemeine Risikofaktoren, Zeitschrift für Orthopädie und Unfallchirurgie. 150(5):503-515.DOI: 10.1055/s-0032-1315345

9. Pourmemari MH, Shiri R. Diabetes as a risk factor for carpal tunnel syndrome: a systematic review and meta-analysis. Diabetic Medicine. 2015; 33(1):10-16. DOI: 10.1111/dme.12855

10. Mansfield M, Thacker M, Sandford F. Psychosocial Risk Factors and the Association With Carpal Tunnel Syndrome: A Systematic Review. HAND. 2017; 13(5):501-508. DOI: 10.1177/1558944717736398

11. Renart I. La mano diabética. Revista Iberoamericana de Cirugía de la Mano. 2015; 43(2):135-141. DOI: 10.1016/j.ricma.2015.09.001

12. Shiri R. Arthritis as a risk factor for carpal tunnel syndrome: a meta-analysis. Scand J Rheumatol. 2016; 45(5):339-346. DOI: 10.3109/03009742.2015.1114141

13. Ellis R, Blyth R, Arnold N, Miner-Williams W. Is there a relationship between impaired median nerve excursion and carpal tunnel syndrome? A systematic review., J Hand Therapy. 2023; 30(1):3-12. DOI: 10.1016/j.jht.2016.09.002

Downloads

Published

2025-07-04

Issue

Section

Revisión de la literatura

How to Cite

Etiology and risk factors of carpal tunnel syndrome: A literature review. (2025). Salutem Scientia Spiritus, 11(1), 86-93. http://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1624