Agenesia dental y cáncer: Revisión de la literatura.
Palabras clave:
Agenesias dentales, hipodoncia, oligodoncia, cáncer, tumores, relación, asociación.Resumen
La agenesia dental es una alteración congénita del desarrollo dental que incluye hipodoncia, oligodoncia y anodoncia, y puede estar influenciada por factores genéticos, ambientales y epigenéticos. En esta revisión de literatura se describen los tipos de agenesia, los dientes más comúnmente afectados y los principales genes implicados como posibles marcadores predictivos como: AXIN2, FGF3, FGF10 y FGFR2. Asimismo, se analiza la evidencia disponible sobre la relación entre agenesia dental y predisposición a diferentes tipos de cáncer, especialmente cáncer colorrectal y de ovario. Aunque los resultados de los estudios no son completamente consistentes, la mayoría sugiere una posible asociación biológica mediada por vías de señalización compartidas, como Wnt/β-catenina. Se destaca la necesidad de continuar realizando investigaciones adicionales con metodologías homogéneas para esclarecer si la agenesia dental puede utilizarse como un indicador clínico temprano de riesgo oncológico, lo cual beneficiaria a los pacientes en poder diagnosticar a tiempo algún tipo de cáncer basados en la agenesia dental.
Descargas
Referencias
1. Hurtado AM, Valencia AM, Hernández J. Agenesia de primeros y segundos molares permanentes: Revisión de literatura y reporte de casos. Agenesis of first and second permanent molar: Literature review and cases reports, revista Estomatológica Salud, 2013; 21(1):39-45. DOI: 10.25100/re.v2lil.5757
2. Cuellar-Chaparro I, López-Reyes M, Espinoza-Jiménez P. Impacto de la agenesia de incisivos laterales maxilares en la oclusión: revisión bibliográfica. International journal of interdisciplinary dentistry. 2024; 17(1):48-52. DOI: 10.4067/S2452-55882024000100048
3. Echeverri Escobar, J, Isaza Guzmán, D, Manco Guzmán, H, Marín Botero, M, Pineda Trujillo, N, Restrepo Perdomo, L, Vásquez Palacio, G Agenesia dental : Epidemiología, clínica y genética en pacientes antioqueños. Avances de Estomatología. 2013; 29 (3):119-30. ISSN: 0213-1285
4. Vélez-Estrada DT, Quiceno-Cortés S, Trujillo-Peña AM, Henao-Bustamante E, Londoño-González MC, Ortiz LM, et al. Artículo de revisión de tema: Alteraciones y anomalías dentales. CES Odontología. 2014; 27(1): 66-77.
5. Ritwik P, Patterson KK. Diagnosis of tooth agenesis in childhood and risk for neoplasms in adulthood. Vol. 18, Ochsner Journal. Ochsner Clinic. 2018; 345-50. DOI: 10.31486/toj.18.0063
6. Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, et al. Advances in tooth agenesis and tooth regeneration. Vol. 22, Regenerative Therapy. Japanese Society of Regenerative Medicine. 2023; 160-8. DOI: 10.1016/j.reth.2022.12.004
7. Paryab M. Congenital Bilateral Missing of Permanent Mandibular Second Molars in a 10-Year-Old Child: A Case Report. J Dent (Shiraz). 2024. DOI: 10.18502/fid.v21i8.15004
8. Bailleul-Forestier I, Molla M, Verloes A, Berdal A. The genetic basis of inherited anomalies of the teeth. Part 1: Clinical and molecular aspects of non-syndromic dental disorders. Vol. 51, European Journal of Medical Genetics. 2008; 273-91. DOI: 10.1016/j.ejmg.2008.02.009
9. Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M. Hypodontia: An Update on Its Etiology, Classification, and Clinical Management. Vol. 2017, BioMed Research International. Hindawi Limited; 2017. DOI: 10.1155/2017/9378325
10. Giovannetti A, Guarnieri R, Petrizzelli F, Lazzari S, Padalino G, Traversa A, et al. Small RNAs and tooth development: The role of microRNAs in tooth agenesis and impaction. J Dent Sci. 2024; 19(4):2150-6. DOI: 10.1016/j.jds.2024.03.013
11. Liu Y, Yang J, Li X, Chen S, Zhu C, Shi Y, et al. Pan-cancer analysis reveals the characteristics and roles of tooth agenesis mutant genes. Medicine (United States). 2023; 102(50):E36001. DOI: 10.1097/MD.0000000000036001
12. Noguera Oll HS, Quintero Gómez MP, Ordóñez Daza DE, Gutierrez Quiceno B. Eating disorders and their impacts in dentistry: an examination of case management evidence. Revista Med. 2024; 32(1):51-62. DOI: 10.18359/rmed.6954
13. De Coster PJ, Marks LA, Martens LC, Huysseune A. Dental agenesis: Genetic and clinical perspectives. Vol. 38, Journal of Oral Pathology and Medicine. 2009; 1-17. DOI: 10.1111/j.1600-0714.2008.00699.x
14. Meade MJ, Dreyer CW. Tooth agenesis: An overview of diagnosis, aetiology and management. Vol. 59, Japanese Dental Science Review. Elsevier Ltd; 2023. 209-18. DOI: 10.1016/j.jdsr.2023.07.001
15. Lammi L, Arte S, Somer M, Järvinen H, Lahermo P, Thesleff I, et al. Report Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer. Vol. 74, Am. J. Hum. Genet. 2004. DOI: 10.1086/386293
16. Chhabra N, Goswami M, Chhabra A. Genetic basis of dental agenesis - Molecular genetics patterning clinical dentistry. Vol. 19, Medicina Oral, Patologia Oral y Cirugia Bucal. 2014. p. 112-9. DOI: 10.4317/medoral.19158
17. Cardoso EF, Martelli DRB, Machado RA, Coletta RD, De Souza JD, Barbosa FT, et al. Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis. Med Oral Patol Oral Cir Bucal. 2018 Jan 20;23(1):e44-8. DOI: 10.4317/medoral.22132
18. Küchler EC, Lips A, Tannure PN, Ho B, Costa MC, Granjeiro JM, et al. Tooth agenesis association with self-reported family history of cancer. J Dent Res. 2013; 92(2):149-55. DOI: 10.1177/0022034512468750
19. Callahan N, Modesto A, Meira R, Seymen F, Patir A, Vieira AR. Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. Arch Oral Biol. 2009; 54(1):45-9. DOI: 10.1016/j.archoralbio.2008.08.002
20. Chalothorn LA, Beeman CS, Ebersole JL, Kluemper CT, Hicks EP, Kryscio RJ, et al. Hypodontia as a risk marker for epithelial ovarian cancer: A case-controlled study. Journal of the American Dental Association. 2008; 139(2):163-9. DOI: 10.14219/jada.archive.2008.0132
21. Bielik P, Bonczek O, Krejčí P, Zeman T, Izakovičová-Hollá L, Šoukalová J, et al. WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer. Clin Oral Investig. 2022; 26(12):7045-55. DOI: 10.1007/s00784-022-04664-x
22. Zhang W, Qu HC, Zhang Y. Association of MSX1 and TGF-β1 genetic polymorphisms with hypodontia: meta-analysis. Genetics and Molecular Research. 2014; 13(4):10007-16. DOI: 10.4238/2014.November.28.5
23. Safari S, Ebadifar A, Najmabadi H, Kamali K, Abedini SS. Screening PAX9, MSX1 and WNT10A Mutations in 4 Iranian Families with Non-Syndromic Tooth Agenesis. International Journal of Molecular and Cellular Medicine. 2023.
24. Schwartz SM. Epidemiology of Cancer. Vol. 70, Clinical Chemistry. Oxford University Press; 2024. 140-9. DOI: 10.1093/clinchem/hvad202
25. Chalothorn LA, Beeman CS, Ebersole JL, Kluemper CT, Hicks EP, Kryscio RJ, et al. Hypodontia as a risk marker for epithelial ovarian cancer: A case-controlled study. Journal of the American Dental Association. 2008; 139(2):163-9. DOI: 10.14219/jada.archive.2008.0132
26. Beard C, Purvis R, Winship IM, Macrae FA, Buchanan DD. Phenotypic confirmation of oligodontia, colorectal polyposis and cancer in a family carrying an exon 7 nonsense variant in the AXIN2 gene. Fam Cancer. 2019; 18(3):311-5. DOI: 10.1007/s10689-019-00120-0
27. Kang EJ, Moon S joo, Lee K, Park IH, Kim JS, Choi YJ. Associations between missing teeth and the risk of cancer in Korea: a nationwide cohort study. BMC Oral Health. 2023; 23(1). DOI: 10.1186/s12903-023-02997-x
28. Fekonja A, Čretnik A, Takač I. Hypodontia prevalence and pattern in women with epithelial ovarian cancer. Angle Orthodontist. 2014; 84(5):810-4. DOI: 10.2319/112813-876.1
29. Quiceno B, Barrera LA. A Scoping Review of Complexity Science in Dentistry. Vol. 12, Dental Hypotheses. 2021. p. 109-17. DOI: 10.4103/denthyp.denthyp_166_20
30. Eiset SE, Schraw J, Sørensen GV, Gregersen PA, Rasmussen SA, Ramlau-Hansen CH, et al. Congenital Tooth Agenesis and Risk of Early-Onset Cancer. JAMA Netw Open. 2024; 7(3):E240365. DOI:10.1001/jamanetworkopen.2024.0365
31. Yin W, Bian Z. Hypodontia, a prospective predictive marker for tumor? Oral Dis. 2016; 22(4):265-73. DOI: 10.1111/odi.12400
32. Matošić Ž, Šimunović L, Jukić T, Granić R, Meštrović S. Examining the link between tooth agenesis and papillary thyroid cancer: is there a risk factor? Observational study. Prog Orthod. 2024; 25(1). DOI: 10.1186/s40510-024-00511-9
33. Paranjyothi M, Kumaraswamy K, Begum LF, Manjunath K, Litha, Basheer S. Tooth agenesis: A susceptible indicator for colorectal cancer? J Cancer Res Ther. 2018; 14(3):527-31. DOI: 10.4103/0973-1482.168997
34. Bonczek O, Krejci P, Izakovicova-Holla L, Cernochova P, Kiss I, Vojtesek B. Tooth agenesis: What do we know and is there a connection to cancer? Vol. 99, Clinical Genetics. 2021. 493-502. DOI: 10.1111/cge.13892
35. Roht L, Hyldebrandt HK, Stormorken AT, Nordgarden H, Sijmons RH, Bos DK, et al. AXIN2-related oligodontia-colorectal cancer syndrome with cleft palate as a possible new feature. Mol Genet Genomic Med. 2023; 11(6). DOI: 10.1002/mgg3.2157
36. Yue H, Liang J, Yang K, Hua B, Bian Z. Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. Eur J Oral Sci. 2016; 124(3):228-33. DOI: 10.1111/eos.12273
37. Bonds J, Pollan-White S, Xiang L, Mues G, D’Souza R. Is there a link between ovarian cancer and tooth agenesis? Eur J Med Genet. 2014; 57(5):235-9. DOI: 10.1016/j.ejmg.2014.02.013
38. Zheng J, He H, Kuang W, Yuan W. Tooth Agenesis: From Genetics to Cancer. Atlas of Science. 2019 Sep.
39. Medina MCG, Bastos RT da RM, Mecenas P, Pinheiro J de JV, Normando D. Association between tooth agenesis and cancer: A systematic review. Journal of Applied Oral Science. 2021; 29. DOI: 10.1590/1678-7757-2020-0955
40. Williams MA, Biguetti C, Romero-Bustillos M, Maheshwari K, Dinckan N, Cavalla F, et al. Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development. Sci Rep. 2018; 8(1). DOI: 10.1038/s41598-018-21368-z
41. Leclerc J, Beaumont M, Vibert R, Pinson S, Vermaut C, Flament C, et al. AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer. Genes Chromosomes Cancer. 2023; 62(4):210-22. DOI: 10.1002/gcc.23112
42. Regier DS, Hart TC. Genetics: The Future Is Now with Interprofessional Collaboration. Vol. 60, Dental Clinics of North America. 2016. p. 943-9. DOI: 10.1016/j.cden.2016.03.005
43. Castillo Taucher S. Actualización en medicina molecular: aplicaciones en la práctica clínica. Medwave. 2010; 10(2). DOI: 10.5867/medwave.2010.02.4376
44. Jensen JM, Skakkebæk A, Gaustadness M, Sommerlund M, Gjørup H, Ljungmann K, et al. Familial colorectal cancer and tooth agenesis caused by an AXIN2 variant: how do we detect families with rare cancer predisposition syndromes? Fam Cancer. 2022; 21(3):325-32. DOI: 10.1007/s10689-021-00280-y
45. Fonseca C de AD, Martelli DRB, Almeida ILF, Mesquita LGM, Dias VO, Martelli-Júnior H. Are dental agenesis and oral clefts clinical markers of ovarian or uterine cancer? Vol. 28, Oral Diseases. 2022. p. 243-4. DOI:10.1111/odi.13720
46. Gutiérrez B, Zuluaga JS, Beltrán EO. The Bangkok 2024 Declaration. Indian Journal of Dental Research. 2025. DOI: 10.4103/ijdr.ijdr_54_25
47. Haddaji Mastouri M, De Coster P, Zaghabani A, Jammali F, Raouahi N, Ben Salem A, et al. Genetic study of non-syndromic tooth agenesis through the screening of paired box 9, msh homeobox 1, axin 2, and Wnt family member 10A genes: a case-series. Eur J Oral Sci. 2018; 126(1):24-32. DOI: 10.1111/eos.12391
48. Lindor NM, Ko Win A, Gallinger S, Daftary D, Thibodeau SN, Silva R, et al. Colorectal cancer and self-reported tooth agenesis. Hereditary Cancer in Clinical Practice. 2014. DOI: 10.1186/1897-4287-12-7
49. Otero L, Lacunza E, Vasquez V, Arbelaez V, Cardier F, González F. Variations in AXIN2 predict risk and prognosis of colorectal cancer. BDJ Open. 2019; 5(1). DOI: 10.1038/s41405-019-0022-z
50. Marvin ML, Mazzoni SM, Herron CM, Edwards S, Gruber SB, Petty EM. AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome. Am J Med Genet A. 2011; 155(4):898-902. DOI: 10.1002/ajmg.a.33927
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2026 María Elizabeth Yánez-Marcayata, Jesús Alberto Hernéndez-Silva, Bruno Gutierrez
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
La Revista Salutem Scientia Spiritus usa la licencia Creative Commons de Atribución – No comercial – Sin derivar: Los textos de la revista son posibles de ser descargados en versión PDF siempre que sea reconocida la autoría y el texto no tenga modificaciones de ningún tipo.
