Biomarcadores en anemia aplásica.

Autores/as

Resumen

Objetivo: Ampliar el conocimiento que se tiene sobre la anemia aplásica, la implicación de los biomarcadores diagnósticos y el uso de los mismos. Materiales y métodos: Se realizó una revisión de la literatura en la base de datos PubMed y Elsevier, usando palabras claves como ¨anemia aplásica¨, ¨biomarcadores¨ y ¨anemia¨. Resultados: Después de revisar la información, se ha concluido que existen varios biomarcadores útiles en la anemia aplásica. Se han descubierto diversas moléculas nuevas que también resultan beneficiosas en el diagnóstico y pronóstico de esta enfermedad, los cuales contribuyen activamente a la insuficiencia hematopoyética, tales como la edad, el sexo, citoquinas como la Trombopoyetina (TPO), el interferón gamma (IFN-γ), factor de necrosis tumoral-a (TNF-α), interleucina 8 (IL-8), IL-12p70, IL17, IL-23 e IL-27, entre otros. Conclusiones: Se evidenció que las citoquinas tienen un papel importante en el proceso de falla de la médula, por su papel como citoquinas anti hematopoyéticas, lo cual es importante para la progresión de la enfermedad y evaluar el nivel de compromiso de la médula ósea. Adicionalmente los miARN son biomarcadores de importancia clínica en el desarrollo de la anemia aplásica, ya que en diversos estudios se evidencia que estos están implicados en la modulación de la expresión génica, lo que podría ser un nuevo enfoque terapéutico para estos pacientes, el único obstáculo, es la disponibilidad de las técnicas en la práctica clínica.

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Biografía del autor/a

Anggy Valentina Soto-Manzano, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Samuel Giraldo-Jiménez, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Luis Miguel Flórez-Castaño, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Julián David Caballero-Henao, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Mateo Uribe-Ramírez, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Lina María Martínez-Sánchez, Universidad Pontificia Bolivariana Medellín (Colombia)

Bacterióloga, Especialista en Hematología, Magister en Educación, Profesora Escuela de Ciencias de la Salud, Facultad de Medicina.

Citas

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Publicado

2023-12-31

Cómo citar

Soto-Manzano, A. V., Giraldo-Jiménez, S., Flórez-Castaño, L. M., Caballero-Henao, J. D., Uribe-Ramírez, M., & Martínez-Sánchez, L. M. (2023). Biomarcadores en anemia aplásica. Salutem Scientia Spiritus, 9(4), 47–52. Recuperado a partir de https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1287

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Sección

Revisión de la literatura