Determinantes prenatales y postnatales tempranos de enfermedades cardiovasculares en el adulto.
Palabras clave:
Disfunción endotelial, Inflamación subclínica, Resistencia a la insulina, EpigenéticaResumen
El enfoque tradicional en la prevención de las Enfermedades Crónicas No Transmisibles (ECNT) como las Enfermedades Cardiovasculares (ECVs) se ha centrado en el estudio e intervención de factores de riesgo clásicos (sedentarismo, malnutrición, tabaquismo, obesidad etc) en la etapa adulta, sin embargo actualmente hay suficiente evidencia que permite considerar que el riesgo de desarrollar una ECVs se inicia desde la etapa prenatal y postnatal temprana. Esta susceptibilidad ocurre en periodos de tiempo de alta plasticidad celular frente a factores de riesgo clásicos y no clásicos, que pueden determinar las instauración fisiológica de disfunción endotelial, resistencia a la insulina, inflamación subclínica crónica y modificaciones epigenéticas estables. Por lo tanto, nuevos esfuerzos en prevención y tratamiento de las ECVs deberían tener en cuenta la salud prenatal y postnatal temprana como un primer paso para reducir la morbimortalidad ocasionada por estas patologías.
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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
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