El Cortisol como biomarcador innovador en la evaluación del Síndrome de Burnout.
Palabras clave:
Burnout, biomarcadores, trabajo, cortisol.Resumen
El síndrome de Burnout es una respuesta crónica al estrés laboral o académico, caracterizada por agotamiento físico, mental y emocional, junto con una disminución de la realización personal y profesional. Este artículo revisa la relación entre el cortisol, principal hormona del estrés, y el Burnout, destacándolo como un biomarcador potencial. Los análisis de cortisol en suero y saliva evidencian niveles significativamente elevados en individuos con diagnóstico de Burnout, en comparación con controles sanos. Además, quienes presentan puntuaciones altas en la subescala de agotamiento emocional (EE) del Maslach Burnout Inventory también muestran un aumento en los niveles de cortisol. El análisis salival de cortisol, al ser no invasivo, se perfila como una herramienta prometedora para la profilaxis, el diagnóstico y el seguimiento de esta patología emergente, que afecta cada vez más a profesionales y estudiantes.
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1. Edú-Valsania S, Laguía A, Moriano JA. Burnout: A Review of Theory and Measurement. Int J Environ Res Public Health. 2022; 19(3):170-8. DOI: 10.3390/ijerph19031780
2. Sullivan V, Hughes V, Wilson DR. Nursing Burnout and Its Impact on Health. Nurs Clin North Am. 2022; 57(1):153-69. DOI: 10.1016/j.cnur.2021.11.011
3. Maresca G, Corallo F, Catanese G, Formica C, Lo Buono V. Coping Strategies of Healthcare Professionals with Burnout Syndrome: A Systematic Review. Medicina. 2022; 58:327-32. DOI: 10.3390/medicina58020327.
4. Ramírez-Elvira S, Romero-Béjar JL, Suleiman-Martos N, Gómez-Urquiza JL, Monsalve-Reyes C, Cañadas-De la Fuente G.A, Albendín-García L. Prevalence Risk Factors and Burnout Levels in Intensive Care Unit Nurses: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health. 2021; 18:114-32. DOI: 10.3390/ijerph182111432
5. Herrera-Briñez LL. Representaciones sociales de los términos salud mental y enfermedad mental en una institución de educación superior en Colombia. Revista Iberoamericana de Psicología. 2022; 15(2):85-96. DOI: 10.33881/2027-1786.rip.15208
6. Groenewal PH, Putrino D, Norman MR. Burnout and Motivation in Sport. Psychiatr Clin North Am. 2021; 44(3):359-72. DOI: 10.1016/j.psc.2021.04.008
7. Kim JH, Kim AR, Kim MG, Kim CH, Lee KH, Park D, et al. Burnout Syndrome and Work-Related Stress in Physical and Occupational Therapists Working in Different Types of Hospitals: Which Group Is the Most Vulnerable? Int J Environ Res Public Health. 2020; 11(14):50-8. DOI: 10.3390/ijerph17145001
8. Zangaro GA, Dulko D, Sullivan D. Understanding and Managing Nurse Burnout. Nurs Clin North Am. 2022; 57(1):11-2. DOI: 10.1016/j.cnur.2021.11.012
9. Vňuková MS, Sebalo I, Brečka T, Anders M, Ptáček R. Burnout syndrome in the Czech Republic: The decreasing trend over the years. Front Public Health. 2023; 11:109-28. DOI: 10.3389/fpubh.2023.1099528.
10. Begin AS, Hata S, Berkowitz LR, et al. Biomarkers of Clinician Burnout. J Gen Intern Med. 2022; 37(2):478-79. DOI: 10.1007/s11606-021-06757
11. Eisenberg RL. Burnout. Acad Radiol. 2022; 29(2):284-86. DOI: 10.1016/j.acra.2021.10.003
12. Wendsche J, Ihle A, Wegge J, Penz MS, Kirschbaum C, Kliegel M. Correction to: Prospective associations between burnout symptomatology and hair cortisol. Int Arch Occup Environ Health. 2022; 95(1):3. DOI: 10.1007/s00420-021-01736-5
13. López-Cortacans G, Pérez-García M, Pérez-García R, Pérez-García D. Burnout syndrome and adverse effects: The unavoidable prevention. Aten Primaria. 2021; 53(10):102-14. DOI: 10.1016/j.aprim.2021.102154
14. Kaltenegger HC, Marques MD, Becker L, et al. Prospective associations of technostress at work, burnout symptoms, hair cortisol, and chronic low-grade inflammation. Brain Behav Immun. 2024; 117:320-29. DOI: 10.1016/j.bbi.2024.01.222
15. Mihai C.T, Dimitriu A, Pantea-Stoian A.C. Smaranda A, Nica A, Alexandru C, et al. Burnout syndrome in Romanian medical residents in time of the COVID-19 pandemic, Medical Hypotheses. 2020; (144):306-19, DOI: 10.1016/j.mehy.2020.109972
16. Golonka K, Gawlowska M, Mojsa-Kaja J, Marek T, Psychophysiological Characteristics of Burnout Syndrome: Resting-State EEG Analysis, BioMed Research International. 2019, 3764-54. DOI: 10.1155/2019/3764354
17. Chen C, Meier ST. Burnout and depression in nurses: A systematic review and meta-analysis. Int J Nurs Stud. 2021; 124:104-99. DOI: 10.1016/j.ijnurstu.2021.104099
18. Leitão J, Pereira D, Gonçalves Â. Quality of Work Life and Contribution to Productivity: Assessing the Moderator Effects of Burnout Syndrome. Int. J. Environ. Res. Public Health. 2021; 18: 24-35. DOI: 10.3390/ ijerph18052425
19. Deneva T, Ianakiev Y, Keskinova D. Burnout Syndrome in Physicians—Psychological Assessment and Biomarker Research. Medicina. 2019; 55(5):209-20. DOI: 10.3390/medicina55050209
20. Raudenská J, Steinerová V, Javůrková A, et al. Occupational burnout syndrome and post-traumatic stress among healthcare professionals during the novel coronavirus disease 2019 (COVID-19) pandemic. Best Pract Res Clin Anaesthesiol. 2020; 34(3):553-60. DOI: 10.1016/j.bpa.2020.07.008
21. Yamaguchi S, Fujita T, Kato S, Yoshimitsu Y, Ito YM, Yano R. Utility of salivary cortisol profile as a predictive biomarker in nurses’ turnover risk: a preliminary study. J Physiol Anthropol. 2024; 43(1):10-9. DOI: 10.1186/s40101-023-00349-w
22. Ungur AP, Bârsan M, Socaciu AI, et al. A Narrative Review of Burnout Syndrome in Medical Personnel. Diagnostics (Basel). 2024; 14(17):1971-90. DOI: 10.3390/diagnostics14171971
23. Bärtl C, Henze GI, Peter HL, et al. Neural and cortisol responses to acute psychosocial stress in work-related burnout: The Regensburg Burnout Project. Psychoneuroendocrinology. 2024; 161:1069-116. DOI: 10.1016/j.psyneuen.2023.106926
24. Zuccarella-Hackl C, Princip M, Holzgang SA, et al. Cortisol Reactivity to Acute Psychosocial Stress in Physician Burnout. Biomedicines. 2024; 12(2):33-45. DOI: 10.3390/biomedicines12020335
25. O’Connor DB, Gartland N, O’Connor RC. Stress, cortisol and suicide risk. Int Rev Neurobiol. 2020; 152:101-30. DOI: 10.1016/bs.irn.2019.11.006
26. James KA, Stromin JI, Steenkamp N, Combrinck MI. Understanding the relationships between physiological and psychosocial stress, cortisol and cognition. Front Endocrinol (Lausanne). 2023; 14:108-59. DOI: 10.3389/fendo.2023.1085950
27. Marlicz W, Koulaouzidis A, Charisopoulou D, et al. Burnout in healthcare - the Emperor’s New Clothes. Prz Gastroenterol. 2023; 18(3):274-80. DOI: 10.5114/pg.2023.131595
28. Pulopulos MM, Baeken C, De Raedt R. Cortisol response to stress: The role of expectancy and anticipatory stress regulation. Horm Behav. 2020; 117-87. DOI: 10.1016/j.yhbeh.2019.104587
29. Lightman SL, Birnie MT, Conway-Campbell BL. Dynamics of ACTH and Cortisol Secretion and Implications for Disease. Endocr Rev. 2020; 41;3-9 DOI: 10.1210/endrev/bnaa002
30. Bringel JMA, Abreu I, Muniz MMC, de Almeida PC, Silva MG. Excessive Noise in Neonatal Units and the Occupational Stress Experienced by Healthcare Professionals: An Assessment of Burnout and Measurement of Cortisol Levels. Healthcare (Basel). 2023; 11(14):2006-30 DOI: 10.3390/healthcare11142002
31. Sherman GD, Mehta PH. Stress, cortisol, and social hierarchy. Curr Opin Psychol. 2020;33:227-32. DOI: 10.1016/j.copsyc.2019.09.013
32. Kusov PA, Kotelevtsev YV, Drachev VP. Cortisol Monitoring Devices toward Implementation for Clinically Relevant Biosensing In Vivo. Molecules. 2023; 28(5):123-53. DOI: 10.3390/molecules28052353
33. Lemos LS, Angarica LM, Hauser-Davis RA, Quinete N. Cortisol as a Stress Indicator in Fish: Sampling Methods, Analytical Techniques, and Organic Pollutant Exposure Assessments. Int J Environ Res Public Health. 2023; 20(13):62-7. DOI: 10.3390/ijerph20136237
34. Moro JDS, Soares JP, Massignan C, et al. BURNOUT SYNDROME AMONG DENTISTS: A SYSTEMATIC REVIEW AND META-ANALYSIS. J Evid Based Dent Pract. 2022; 22(3):101-24. DOI: 10.1016/j.jebdp.2022.101724
35. Mithen LM, Weaver N, Walker FR, Inder KJ. Feasibility of biomarkers to measure stress, burnout and fatigue in emergency nurses: a cross-sectional study. BMJ Open. 2023; 13(8) DOI: 10.1136/bmjopen-2023-072668
36. Velando-Soriano A, Ortega-Campos E, Gómez-Urquiza JL, Ramírez-Baena L, De La Fuente EI, Cañadas-De La Fuente GA. Impact of social support in preventing burnout syndrome in nurses: A systematic review. Jpn J Nurs Sci. 2020; 17(1):122-69. DOI: 10.1111/jjns.12269
37. Luo J, Zhou C, Wang S, et al. Cortisol synergizing with endoplasmic reticulum stress induces regulatory T-cell dysfunction. Immunology. 2023; 170(3):334-43. DOI: 10.1111/imm.13669
38. Appiani FJ, Rodríguez Cairoli F, Sarotto L, Yaryour C, Basile ME, Duarte JM. Prevalence of stress, burnout syndrome, anxiety and depression among physicians of a teaching hospital during the COVID-19 pandemic.. Arch Argent Pediatr. 2021; 119(5):317-24. DOI: 10.5546/aap.2021.eng.317
39. Vicković S, Zdravković R, Maričić-Prijić S, et al. Salivary cortisol as a biomarker of stress in surgical patients. J Med Biochem. 2023; 42(3):469-75. DOI: 10.5937/jomb0-42011
40. Vasanthi V, Thavarajah R, Joshua E, Rao UK, Ranganathan K. Evaluation of stress among dental undergraduates and postgraduates using salivary cortisol as a biomarker. Indian J Dent Res. 2022; 33(3):263-66. DOI: 10.4103/ijdr.ijdr_498_21
41. Knezevic E, Nenic K, Milanovic V, Knezevic NN. The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders. Cells. 2023; 12(23):272-6. DOI: 10.3390/cells12232726
42. Romanova Z, Hrivikova K, Riecansky I, Jezova D. Salivary testosterone, testosterone/cortisol ratio and non-verbal behavior in stress. Steroids. 2022; 182:108999. DOI: 10.1016/j.steroids.2022.108-99
43. Kraemer WJ, Ratamess NA, Hymer WC, Nindl BC, Fragala MS. Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise. Front Endocrinol (Lausanne). 2020; 11-33. DOI: 10.3389/fendo.2020.00033
44. Choi MH. Clinical and Technical Aspects in Free Cortisol Measurement. Endocrinol Metab (Seoul). 2022; 37(4):599-607. DOI: 10.3803/EnM.2022.1549
45. Clow A, Smyth N. Salivary cortisol as a non-invasive window on the brain. Int Rev Neurobiol. 2020; 150:1-16. DOI: 10.1016/bs.irn.2019.12.003
46. Rossini Gajšak L, Vogrinc Ž, Čelić Ružić M, et al. Salivary cortisol response to psychosocial stress in patients with first-episode psychosis. Croat Med J. 2021; 62(1):80-9. DOI: 10.3325/cmj.2021.62.80
47. Şemsi R, Kökbaş U, Arslan B, Ergünol E, Kayrın L, Sepici Dinçel A. The Saliva Cortisol and Amylase Levels Related with Stress Response Compared by Different Analytical Methods. Appl Biochem Biotechnol. 2022; 194(3):1166-77. DOI: 10.1007/s12010-021-03676-9
48. Ibar C, Fortuna F, Gonzalez D, et al. Evaluation of stress, burnout and hair cortisol levels in health workers at a University Hospital during COVID-19 pandemic. Psychoneuroendocrinology. 2021; 128:105-213. DOI: 10.1016/j.psyneuen.2021.105213
49. McCanlies EC, Leppma M, Mnatsakanova A, et al. Associations of burnout with awakening and diurnal cortisol among police officers. Compr Psychoneuroendocrinol. 2020; 4:100-16. DOI: 10.1016/j.cpnec.2020.100016
50. Ciobanu AM, Damian AC, Neagu C. Association between burnout and immunological and endocrine alterations. Rom J Morphol Embryol. 2021; 62(1):13-8. DOI: 10.47162/RJME.62.1.02
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Derechos de autor 2026 Valery Leilany Briñez-Prada
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