Pancitopenia: Enfoque diagnóstico. Revisión de la literatura
Resumen
La pancitopenia es una alteración hematológica que puede poner en peligro la vida del paciente en muchas ocasiones. Su diagnóstico supone un desafío para el médico tratante dada su amplia posibilidad de etiologías. El objetivo es hacer un acercamiento en el abordaje diagnóstico de un paciente con pancitopenia. La búsqueda de información se realizó en las bases de datos: PubMed, Google académico, Clinical Key y Medline, utilizando descriptores en español e inglés. En la práctica clínica se ha visto la importancia de saber abordar correctamente a los pacientes con pancitopenia e identificar la causa subyacente, ya que un gran número de pacientes cursan con una etiología reversible y el diagnóstico oportuno puede salvar su vida.
Descargas
Citas
Gnanaraj J, Parnes A, Francis C, Go R, Takemoto C, Hashmi S. Approach to pancytopenia: Diagnostic algorithm for clinical hematologists. Blood Rev. 2018; 32(5):361-367. DOI: 10.1016/j.blre.2018.03.001
Vargas-Carretero CJ, Fernandez-Vargas OE, Ron-Magaña AL, Padilla-Ortega JA, Ron-Guerrero CS, Barrera-Chairez E. Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature. Hematology. 2019; 24(1):399-404. DOI: 10.1080/16078454.2019.1590961.
Sarbay H. Comparison of the severity of cytopenias with etiologic factors in patients with pancytopenia and bicytopenia. Pan Afr Med J. 2019; 34:149. DOI: 10.11604/pamj.2019.34.149.18749.
Rubio P, Riesco S. Pancitopenia: valoración clínica y diagnóstica. An Pediatr Contin. 2012;10(4):217-21
Geissler K. Pancytopenia. A diagnostic challenge?. memo-Magazine of European Medical Oncology. 2021; 14(x): 355-359. DOI: 10.1007/s12254-021-00757-7
Pendkur G, Singhal P, Somasundaram V, Raghavendra SK, Sharma S. Clinicopathological study of new onset pancytopenia: An experience of largest study from a tertiary care center of Western India. Medical Journal of Dr. DY Patil Vidyapeeth. 2021; 14(3):283-91.
Nafil H, Tazi I, Sifsalam M, Bouchtia M, Mahmal L. Profil etiologique des pancytopénies chez l’adulte a Marrakech (Maroc) [Etiological profile of pancytopenia in adults in Marrakesh, Morocco]. East Mediterr Health J. 2012; 18(5):532-6.
Ahmad N, Akhter N, Ahmad T. Pancytopenia - A Study on Clinical and Etiological Profile at a Tertiary Care Institute. Int J Sci Stud 2018; 6(1):33-36. DOI: 10.17354/ijss/2018/108
Pozuelo R, López P, López-Dóriga P. Pancitopenia en el curso de infección por SARS-CoV-2. Med Clin (Barc). 2020; 155(8):364-365. DOI: 10.1016/j.medcli.2020.06.016.
Vargas-Carretero CJ, Fernandez-Vargas OE, Ron-Magaña AL, Padilla-Ortega JA, Ron-Guerrero CS, Barrera-Chairez E. Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature. Hematology. 2019; 24(1):399-404. DOI: 10.1080/16078454.2019.1590961.
Gupta M, Chandna A, Kumar S, Kataria SP, Hasija S, Singh G, Sen R. Clinicohematological Profile of Pancytopenia: A Study from a Tertiary Care Hospital. Dicle Med J. 2016; 43(1):5-11. DOI: 10.5798/diclemedj.0921.2016.01.0629
Muneer K, Baig M, Sheikh BA, Abid MA, Farooq H, Kamal A. To Determine the Common Causes Leading to Pancytopenia in Patients Presenting to Tertiary Care Hospital, Lahore. Pak J Med Sci. 2022; 16(03):283-285.
Jain A, Naniwadekar M. An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. BMC hematol. 2013; 13(1): 1-9. DOI: 10.1186/2052-1839-13-10
Das Makheja K, Kumar Maheshwari B, Arain S, Kumar S, Kumari S, Vikash. The common causes leading to pancytopenia in patients presenting to tertiary care hospital. Pak J Med Sci. 2013; 29(5):1108-1111. DOI: 10.12669/pjms.295.3458
Chiravuri S, De Jesus O. Pancytopenia [Internet]. Treasure Island (FL): StatPearls; 2022. [revised 2022; cited 2024 Enero 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563146/.
Groarke EM, Young NS, Calvo KR. Distinguishing constitutional from acquired bone marrow failure in the hematology clinic. Best Pract Res Clin Haematol. 2021; 34(2):101275. DOI: 10.1016/j.beha.2021.101275.
Passamonti F, Mora B. Myelofibrosis. Blood, The Journal of the American Society of Hematology. 2023; 141(16):1954-70.
Sastow D, Mascarenhas J, Tremblay D. Thrombocytopenia in Patients With Myelofibrosis: Pathogenesis, Prevalence, Prognostic Impact, and Treatment. Clin. Lymphoma Myeloma Leuk. 2022; 22(7):e507-e520. DOI: 10.1016/j.clml.2022.01.016.
Dores GM, Curtis RE, Linet MS, Morton LM. Cause-specific mortality following polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the US population, 2001-2017. Am. J. Hematol. 2021; 96(12):E451.
Asher S, McLornan DP, Harrison CN. Current and future therapies for myelofibrosis. Blood Rev. 2020; 42:100715. DOI: 10.1016/j.blre.2020.100715.
Salama ME. Important Pathologic Considerations for Establishing the Diagnosis of Myelofibrosis. Hematol Oncol Clin N Am. 2021; 35 (2): 267-278.
Mendoza-Álvarez SA, Moranchel García L, Rodríguez-Corchado BG, Deras-Quiñones A. Mielofibrosis primaria manifestada como fiebre de origen desconocido. Med Int Méx. 2018; 34(6):1000-1006. DOI: 10.24245/mim. v34i6.2000.
Masarova L, Bose P, Pemmaraju N, Chifotides H, Zhou L, Estrov Z, Kantarjian H, Verstovsek S. Overall and cause specific changes in mortality of patients with myelofibrosis over the last 3 decades. HemaSphere. 2021; 524-5.
Furlong E, Carter T. Aplastic anaemia: Current concepts in diagnosis and management. J Paediatr Child Health. 2020; 56 (7): 1-6. DOI: 10.1111/jpc.14996.
Medinger M, Drexler B, Lengerke C and Passweg J. Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment. Front. Oncol. 2018; 8(587). DOI: 10.3389/fonc.2018.00587.
Khalid I, Abbas F, Mustafa Z, Kamran M. Association of Various Etiological ell Res. J Factors with Idiopathic Acquired Aplastic Anemia. IJHOSCR. 2022; 2(1):19-25.
Giudicea V, Selleri C. Aplastic anemia: Pathophysiology. Semin. Hematol. 2022; 59(1):13-20. DOI: 10.1053/j.seminhematol.2021.12.002.
Ahmed P, Chaudhry QU, Satti TM, Mahmood SK, Ghafoor T, Shahbaz N, Khan MA, Satti HS, Akram Z, Iftikhar R. Epidemiology of aplastic anemia: a study of 1324 cases. Hematology. 2020; 25(1):48-54.
Schwinda S, Jentzscha M, Kubascha AS, Metzeler KH, Platzbecker U. Myelodysplastic syndromes:Biological and therapeutic consequences of the evolving molecular aberrations landscape. Neoplasia. 2021; 23(11): 1101-1109. DOI: 10.1016/j.neo.2021.09.002.
Sekeres MA, Taylor J. Diagnosis and treatment of myelodysplastic syndromes: a review. Jama. 2022; 328(9):872-80.
Fenaux P, Platzbecker U, Ades L. How we manage adults with myelodysplastic syndrome. Br. J. Haematol. 2020; 189(6):1016-27.
Saygin C, Carraway HE. Current and emerging strategies for management of myelodysplastic syndromes. Blood Rev. 2021; 48:100791. DOI: 10.1016/j.blre.2020.100791.
Crisp R, Bestach Y, Kornblihtt L, Lazzarino C, Iastrebner M, Gonzalez J, Arbelbide J, Belli CB. Preferencias y limitaciones de los hematólogos para afrontar la complejidad de los síndromes mielodisplásicos. Medicina (Buenos Aires). 2019; 79:174-184.
González-Martínez DF, CabreraVelasco CE, Chilitio-Zemanate PA, Verhelst-Solano JL. Pancitopenia inducida por bajas dosis de metotrexato. Rev CES Med 2019; 33(2):119-125.
Pai MP, Mercier RC, Koster SA. Epidemiology of vancomycin-induced neutropenia in patients receiving home intravenous infusion therapy. Ann Pharmacother. 2006; 40(2):224-8.
Brandariz D, Guarc E, García B, Picón R, Hernández V. Pancitopenia inducida por vancomicina: descripción de un caso. Farm Hosp. 2018; 42(1):31-2.
de Pascual RMPR, Pardo PL, Bonnardeaux PL-Doriga. Pancitopenia en el curso de infeccion por SARS-CoV-2. Med Clin. 2020; 155(8):364-365. DOI: 10.1016/j.medcli.2020.06.016.
Hayat AS, Khan AH, Baloch GH, Shaikh N. Pancytopenia; study for clinical features and etiological pattern of at tertiary care settings in Abbottabad. Professional Med J. 2014;21(1): 060-065.
Reshma ST, Giti S, Chowdhury SA, Rabbani MG, Kabir MI, Rabby MA. Clinico-haematological study of pancytopenia. Med Today. 202; 33(1):12-8.
Das J, Khonglah Y, Tiewsoh I, Chowdhury Z, Barman H. Utility of reticulocyte indices in the diagnosis of pancytopenia. J Family Med Prim Care. 2022; 11(4):1335-1340. DOI: 10.4103/jfmpc.jfmpc_1121_21.
Chowdhury MRK, Begum A, Rashid MH, Hasan MK. Pancytopenia: A Challenging Problem for treating Physician. Haematol J Bangladesh. 2018; 2(1):22-28. DOI: 10.37545/haematoljbd201814.
Chouhan A, Ahmad F, Jain M. A Clinico-Haematological Study of Causes of Pancytopenia. J. Evol. Med. Dent. Sci. 2021; 10(40):3533-8. DOI: 10.14260/jemds/2021/716.
Gayathri BN, Rao KS. Pancytopenia: A Clinico Hematological Study. J Lab Physicians. 2011; 3(1): 15-20. DOI: 10.4103/0974-2727.78555.
Nanwani P, Khatri S. Pancytopenia - Diagnosis on Bone Marrow Aspiration. Indian J Basic Appl Med Res. 2016; 5(2): 723-732.
Shah R, Patel K. Evaluation of bone marrow in patients with pancytopenia. Panacea J Med Sci. 2020; 10(3):209-215.
Gupta S, Goel D, Agrawal A, Agrawal M. Clinico Hematological study in cases of pancytopenia. J. Cardiovasc. Dis. 2022; 13(05):1620-1627.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone Marrow Examination in Cases of Pancytopenia. J Nepal Med Assoc 2008; 47(169):12-7.
Desalphine M, Bagga PK, Gupta PK, Kataria AS. To Evaluate the Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Pancytopenia. J. Clin. Diagnostic Res. 2014; 8(11): FC11-FC15. DOI: 10.7860/JCDR/2014/9042.5169.
Poorana PP, Subhashree AR. Role of Absolute Reticulocyte Count in Evaluation of Pancytopenia-A Hospital Based. Study. J. Clin. Diagnostic Res. 2014; 8(8): FC01-FC03. DOI: 10.7860/JCDR/2014/8949.4704.
Weinzierl EP, Arber DA. The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia. Am J Clin Pathol. 2013; 139:9-29. DOI: 10.1309/AJCP50AEEYGREWUZ.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Natalia Morales-Quintero, Lina María Martínez-Sánchez
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
La Revista Salutem Scientia Spiritus usa la licencia Creative Commons de Atribución – No comercial – Sin derivar: Los textos de la revista son posibles de ser descargados en versión PDF siempre que sea reconocida la autoría y el texto no tenga modificaciones de ningún tipo.