Efectos de la administración de hidroxiurea en pacientes con necrosis avascular en anemia de células falciformes.

Autores/as

Palabras clave:

Anemia de células falciformes, Hidroxiurea, Osteonecrosis, Hemoglobinopatías, Antidrepanocíticos

Resumen

La hidroxiurea es un agente terapéutico utilizado en el tratamiento de la anemia de células falciformes o drepanocitosis. Esta patología es un trastorno genético autosómico recesivo. Su complicación más frecuente es la osteonecrosis, que afecta principalmente la epífisis de huesos largos como la cabeza y cóndilos femorales, cabeza humeral y la porción distal de la tibia. El objetivo del presente artículo es demostrar los efectos adversos de la administración de hidroxiurea en pacientes con necrosis avascular en anemia de células falciformes y exponer algunos tratamientos emergentes para esta patología. Para ello se realizó una revisión bibliográfica a través de las bases de datos de Pubmed y Elsevier de los últimos 10 años, sobre el fármaco utilizado para el tratamiento de la anemia de células falciformes y sí su administración conduce o no a la generación de la osteonecrosis. Como conclusión, se han descrito diversos efectos adversos ocasionados por la administración de hidroxiurea en pacientes con la patología mencionada.

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Biografía del autor/a

Carolina Durango-Sánchez, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Laura Duque-Echeverri, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Lina María Martínez-Sánchez, Universidad Pontificia Bolivariana Medellín (Colombia)

Bacterióloga, Especialista en Hematología, Magíster en Educación, Grupo de Investigación en Salud Clínica y Quirúrgica, Línea de Hematología, Universidad Pontificia Bolivariana.

Valeria Vásquez-Estrada, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Laura Herrera-Almanza, Universidad Pontificia Bolivariana Medellín (Colombia)

Estudiante de Medicina.

Citas

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Publicado

2022-06-30

Cómo citar

Durango-Sánchez, C., Duque-Echeverri, L., Martínez-Sánchez, L. M., Vásquez-Estrada, V., & Herrera-Almanza, L. (2022). Efectos de la administración de hidroxiurea en pacientes con necrosis avascular en anemia de células falciformes. Salutem Scientia Spiritus, 8(2), 18–24. Recuperado a partir de https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/674

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